Central Sensitization

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Central sensitization pain should be included in (central) neuropathic pain.

Dr. Nijs et al (1) provided criteria for the classification of central sensitization (CS) pain. Peripheral neuro-pathic pain and nociceptive pain cause CS in the central nervous system if the 2 kinds of pain persist. Therefore, pure peripheral neuropathic pain and pure nociceptive pain are rare in clinical practice. I believe that CS is one of causes of central neuropathic pain. CS pain may be ...

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Gabapentin inhibits central sensitization during migraine

Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and prot...

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Intermittent Hypoxia-Induced Sensitization of Central Chemoreceptors

26 Hypertension elicited by chronic intermittent hypoxia (CIH) is associated with elevated 27 activity of the thoracic sympathetic nerve (tSN) that exhibits an enhanced respiratory modulation 28 reflecting a strengthened interaction between respiratory and sympathetic networks within the 29 brainstem. Expiration is a passive process except for special metabolic conditions as hypercapnia 30 when...

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Post-treatment lyme syndrome and central sensitization.

Central sensitization is a process that links a variety of chronic pain disorders that are characterized by hypersensitivity to noxious stimuli and pain in response to non-noxious stimuli. Among these disorders, treatments that act centrally may have greater efficacy than treatments acting peripherally. Because many individuals with post-treatment Lyme syndrome (PTLS) have a similar symptom clu...

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Objective(s): The present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. Materials and Methods: Oxaliplatin (5 mg/kg) or saline was administered to adult male Sprague-Dawley rats.  Gabapentin (60 mg/kg, IP) or vehicle was injected daily. Mechanical allodynia was assessed us...

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ژورنال

عنوان ژورنال: Anesthesiology

سال: 2007

ISSN: 0003-3022

DOI: 10.1097/01.anes.0000264769.87038.55